Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on April 26, 2009

Described as a Pfizer PAK4 candidate of indeterminate status.


Thanks Redferret for the structure.  Keep’m coming.  The candidate is described as a win from the combined knowledge base gained by the Sugen and Pharmacia Pfizer mergers.



3 Responses to “PF-3758309”

  1. Orgmed said

    and from Nerviano’s A2K I guess?
    Is this specific for Group II or any activity on Pak1.
    The previously reported Pak4 the smiles: O=C(CC1=CC=C(F)C=C1)NC2=NNC3=C2CN(C(C[C@@H](C)CN(C)C)=O)C3(C)C
    WO 2007072153 (Pfizer).

  2. milkshake said

    sorry but the left structure is not Sugen but Agouron. Some 3-subst indazoles were done at Sugen also but these ones looked pretty unfamiliar. The right structure comes from Nerviano in Italy (they have been totally in love with various fused 3-aminopyrazoles). Both Nerviano and Sugen were part of Pharmacia but the competition was friednly. That cannot be said about Agouron – people there were constantly badmouthing the Sutent-like oxindoles, and called the results “fake” – very up to the point when it got approved.

  3. petros said

    In Phase I for solid tumors from August 2009 NCT00932126

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