KinasePro

Kinase Chemistry – Just a year and a half behind the times.

PF-3758309

Posted by kinasepro on April 26, 2009

Described as a Pfizer PAK4 candidate of indeterminate status.

CC1(C)N(C(N[C@H](CN(C)C)C2=CC=CC=C2)=O)CC3=C1NN=C3NC4=C(SC=C5)C5=NC(C)=N4

Thanks Redferret for the structure.  Keep’m coming.  The candidate is described as a win from the combined knowledge base gained by the Sugen and Pharmacia Pfizer mergers.

CC(C1=C(C2)C(NC(C3=CC=CC(OC4=CC=CC=C4)=C3)=O)=NN1)(C)N2C(N5CCN(C)CC5)=O.O=C(C(C=C6)=CC7=C6NN=C7C8=NC9=C(C=CC=C9)N8)N[C@@H](C%10=CC=CC=C%10)CN(C)C

Advertisements

3 Responses to “PF-3758309”

  1. Orgmed said

    and from Nerviano’s A2K I guess?
    Is this specific for Group II or any activity on Pak1.
    The previously reported Pak4 the smiles: O=C(CC1=CC=C(F)C=C1)NC2=NNC3=C2CN(C(C[C@@H](C)CN(C)C)=O)C3(C)C
    WO 2007072153 (Pfizer).

  2. milkshake said

    sorry but the left structure is not Sugen but Agouron. Some 3-subst indazoles were done at Sugen also but these ones looked pretty unfamiliar. The right structure comes from Nerviano in Italy (they have been totally in love with various fused 3-aminopyrazoles). Both Nerviano and Sugen were part of Pharmacia but the competition was friednly. That cannot be said about Agouron – people there were constantly badmouthing the Sutent-like oxindoles, and called the results “fake” – very up to the point when it got approved.

  3. petros said

    In Phase I for solid tumors from August 2009 NCT00932126

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

 
%d bloggers like this: