KinasePro

Kinase Chemistry – Just a year and a half behind the times.

AS-703026

Posted by kinasepro on April 24, 2009

>> Update – this structure has been revised from the butyl amide – This is (i believe) the correct structure >>

EMD-Serono’s got ‘a ph1 non-hydroxamate ‘ATP Collaborative’ Mek inhibitor.

O=C(C1=C(C=NC=C1)NC2=CC=C(C=C2F)I)NC[C@H](O)CO

via Ghost, & WO/2006/045514

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5 Responses to “AS-703026”

  1. ATP->ADP said

    Are you sure it is a non-hydroxamate?

  2. ATP->ADP said

    but later i realized, if you have iodo, it really doesn’t matter what you have anywhere else!

  3. KinaseNerd said

    They actually made the hydroxamate first, but it turned out to be less cell active. Then they switched to the amide ….

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