KinasePro

Kinase Chemistry – Just a year and a half behind the times.

CH-4987655

Posted by kinasepro on April 23, 2009

Some have walked a country mile to get away from the hydroxamate, others think nothing of tacking ‘nother one on:  Its Chugai’s ‘ATP-Collaborative’  Ph1 MEK inhibitor: Ro-4987655 / CH-4987655.  More potent, stable, and soluble…

O=C(NOCCO)C1=C(NC2=CC=C(I)C=C2F)C(F)=C(F)C(CN3OCCCC3=O)=C1

Reduced signs of hydrolysis to the inactive acid and no BBB penetration.(preclinically)

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