KinasePro

Kinase Chemistry – Just a year and a half behind the times.

WO/2009/035159

Posted by kinasepro on April 13, 2009

Possibly SAR-502250 its a Mitsubishi / Sanofi TPK1/GSK3 inhibitor:

CC1=NOC(C(C=C2)=CC=C2[C@H](OCC3)CN3C(N4C)=NC(C5=NC=NC=C5)=CC4=O)=N1

for Alzheimer’s & Diabetes

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2 Responses to “WO/2009/035159”

  1. milkshake said

    A nice design. No NH is a good thing, for brain penetration.

  2. Orgmed said

    These days we see quite a few -C-C linkage at 4th position.
    This is very unique with morpholin direct substitution at 2nd position. Good rationale of introducing oxadiazole on aryl ring.

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