Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on April 13, 2009

Possibly SAR-502250 its a Mitsubishi / Sanofi TPK1/GSK3 inhibitor:


for Alzheimer’s & Diabetes

2 Responses to “WO/2009/035159”

  1. milkshake said

    A nice design. No NH is a good thing, for brain penetration.

  2. Orgmed said

    These days we see quite a few -C-C linkage at 4th position.
    This is very unique with morpholin direct substitution at 2nd position. Good rationale of introducing oxadiazole on aryl ring.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: