Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on April 13, 2009

Aveo’s Ph1 irreversibleĀ  Erbb inhibitor:


via Mitsubishi

2 Responses to “AV-412”

  1. Ed said

    I look at this and i wonder whether such dimethyl propargyls can protonate and eliminate N-methylpiperazine, generating a nicely conjugated allene.

  2. kinasepro said

    This one makes you want to draw Cope, and Diels-Alder products, but hey maybe its just stable!

    Cancer Science Article

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