KinasePro

Kinase Chemistry – Just a year and a half behind the times.

AV-412

Posted by kinasepro on April 13, 2009

Aveo’s Ph1 irreversibleĀ  Erbb inhibitor:

C=CC(NC1=CC2=C(N=CN=C2C=C1C#CC(C)(C)N3CCN(CC3)C)NC4=CC=C(C(Cl)=C4)F)=O

via Mitsubishi

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2 Responses to “AV-412”

  1. Ed said

    I look at this and i wonder whether such dimethyl propargyls can protonate and eliminate N-methylpiperazine, generating a nicely conjugated allene.

  2. kinasepro said

    This one makes you want to draw Cope, and Diels-Alder products, but hey maybe its just stable!

    Cancer Science Article

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