KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Roche’s JNK

Posted by kinasepro on April 11, 2009

An awful lot like Takeda’s JNK

r-jnk

Roche: WO/2008/138920; WO/2009/015917
Takeda:  BMCL; WO/2003/068750; WO/2002/062764

I  detect some similarity to SP-600125 within this class, but a cross screen of the older DPPIV inhibitors seem like a more likely origin.

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3 Responses to “Roche’s JNK”

  1. gyges said

    I detect some similarity to” …

    If you have the time, how about posting some sort of structure vs activity analysis?

  2. kinasepro said

    There’s limited SAR that can be gleaned from Roche patent apps… Otherwise the Takeda BMCL will give you about as good as your going to get!

    Noteably, the pictured structure is example 18 from ’09 app where they show it achieves an ED50 of IL6 production @ 3 mg/Kg in rat.

  3. gyges said

    thanks for the reply!

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