KinasePro

Kinase Chemistry – Just a year and a half behind the times.

BMS-777607

Posted by kinasepro on March 26, 2009

BMS homegrown Ph1 c-Met / AXL / Ron Inhibitor.  As of now PDB 3F82 has not yet been released.

O=C(C1=C(OCC)C=CN(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C(Cl)C(N)=NC=C4)C(F)=C3

The N-Oxide is a major metabolite, and from the trial notes its either toxic, potent, or prevalent… The J Med Chem doesn’t mention it.

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One Response to “BMS-777607”

  1. Petros said

    The backup BMS-817378 is identified in this week’s WO-2009094427

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