KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Gsk-690693

Posted by kinasepro on March 18, 2009

It’s an AKT inhibitor, and its been Terminated & WithdrawnWonder why.

CC(C)(C#CC1=NC=C(C2=C1N=C(N2CC)C3=NON=C3N)OC[C@@H]4CNCCC4)OCancer Res, Blood, J Med Chem, Dartmouth?

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3 Responses to “Gsk-690693”

  1. fromsgc said

    I think that’ why:
    http://clincancerres.aacrjournals.org/cgi/content/full/15/1/217

  2. milkshake said

    Glaxo published lots of stuff around the aminofurazane monsters, also for Rho kinase if i remember correctly. And those series were also discontinued, for animal toxicity reasons. They were not sure if the problem mechanism based. But just looking at the structure one can suffer a seizure.

  3. petros said

    Two follow ups now in Phase I
    GSK2141795 and GSK21110183

    and Pfizer is also in the clinic with PF-04691502

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