KinasePro

Kinase Chemistry – Just a year and a half behind the times.

AMG-458

Posted by kinasepro on March 18, 2009

Here’s one where they do tell us why its off the pipeline:

COC1=CC2=C(C(OC3=CC=C(N=C3)NC(C4=C(C)N(N(C4=O)C5=CC=CC=C5)CC(O)(C)C)=O)=CC=N2)C=C1

J Med Chem -> Chem Res Tox

COC1=CC2=C(C(SC[C@H](NC(CCCC(O)=O)=O)C(NCC(O)=O)=O)=CC=N2)C=C1

makes you wonder about XL-880, E-7080, & AV-951

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