Kinase Chemistry – Just a year and a half behind the times.

Jnk Science

Posted by kinasepro on September 9, 2008

Roche Palo Alto just published 3E7O: JNK2 (7x mutant) bound to an indazole:

Which brings up that nearly two years ago I suggested CC-401 may be from an ’06 Celgene application.  Right flavor wrong compound, the drawn compound is CG-930 (IND filed Dec 18, 2007 – claimed in Ph1 for fibrotic diseases).  As NCI suggests CC-401 is an SP-600125 analog which incidentally is no longer on the CG pipeline.   C12=C(C=C(C=C2)C3=NN=CN3)C(C4=CC(OCCN5CCCCC5)=CC=C4)=NN1

That’s life on the edge for yah.


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