KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Chiron’s got Pim

Posted by kinasepro on September 4, 2008

WO/2008/106692 is Novartis’ Emeryville’s Pim1,2,3 < 1uM offering:

O=C(C1=C(N)C=CC(C2=CC(C(N(C)C)=O)=CC=C2F)=N1)NC3=C(N4C[C@@H](N)CCC4)C=CN=C3

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2 Responses to “Chiron’s got Pim”

  1. Orgmed said

    Any idea what the Pim1 activity would be for the Chiron/NVS?.
    hERG, CYP450 posibilities.

  2. Orgmed said

    This compound may suffer with selectivity issues, metabolic stability and hERG?.
    Any comments.

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