KinasePro

Kinase Chemistry – Just a year and a half behind the times.

WO/2007/084560

Posted by kinasepro on October 27, 2007

Celgene S.D. aka Signal has a series of v600e active thienopyrimidines that also appear to hit the non-kinase PDE4.

ClC1=C(Cl)C=C(C2=NC(N[C@H](CC)CO)=NC3=C2C(N)=C(C(N)=O)S3)C=C1.NC4=C(C(N)=O)SC5=C4C(C6=CC(NC(NC7=CC=C(C(F)(F)F)C=C7)=O)=CC=C6)=NC(NC(C)(C)CN)=N5

WO/2007/084560

(NH2 > S)

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