Steal This Document
Posted by kinasepro on October 10, 2007
You may have noticed the Ro5 tab above. Here’s the spreadsheet.
To the best of my knowledge it’s the most complete list of clinical stage kinase inhibitors in existence. There are bound to be errors and omissions though, so while I of course don’t want anything proprietary please send me references and structures as appropriate. I appreciate the help.
TotallyMedicinal said
Nice one.
Cyclacel have a CDK inhibitor (seliciclib) in Phase 2 (although this one seems to have been in the clinic for ever), and a Aurora inhibitor in Phase 1 (CYC-116).
http://www.cyclacel.com/cyc/ourcompany/pipeline/
Seliciclib structure is on wikipedia
http://en.wikipedia.org/wiki/Seliciclib
TotallyMedicinal said
PS I don’t see KC706 (Kemia) on your list. But then I didn’t see CYC202, so what do I know…..
http://www.kemia.com/brandomatic/templates/pipeline.htm
Interetsed in PI3k said
Another PI3K inhibitor in Phase 1 is BEZ235 from Novartis, in Vegas
http://www.nevadacancerinstitute.org/science.aspx?id=722
Wavefunction said
What’s the deal with roscovitine? It’s pretty non-selective. What are the tox issues associated with blocking CDK2? Just curious.
oleg said
Somehow I can not “steal” ph3 and adv pages.
I can select, copy and paste ph1 and ph2
but ph3 and adv rows come as a sinle string without separators…
TotallyMedicinal said
You got this one?
http://www.ariad.com/wt/page/ap23573
kinasepro said
I must plead ignorance in the ways of mTor inhibitors… Thats one kinase you won’t (yet) find anything about here. ;(
as for the ph3 and a tabs… Try another browser?
TMS said
http://www.quantcast.com/kinasepro.wordpress.com
pf01273 said
I couldn’t see OSI-906 which is an IGF-1R inhibitor in PI:
http://www.osip.com/OSI_906
singh said
can’t see the spreadsheet!…
ALso any way you will be publishing this list (updated 2010)?