KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for July, 2007

PDB Update

Posted by kinasepro on July 3, 2007

2J0K FAK; Harvard, Cell, 129, 1177
2J0M (companion to: 2J0J, 2J0L)

2PTO P38 F169Y Mutant; Locus Discovery; Biochem;
2PV5 P38 D168G mutant (companions to 2pkj, 2ptj)

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WO/2007/071955

Posted by kinasepro on July 2, 2007

Title’d app is from AstraZeneca and has ’bout 82 thiazoles said to hit c-Fms.

O=C(NC1=CN=C(C)S1)C2=CC(NC(C3=CC=CC(C(F)(F)F)=C3)=O)=CC=C2Cl

click for the guess Read the rest of this entry »

Posted in Astra, c-fms | 2 Comments »

Chroma Ther. ‘n’ Aurora A

Posted by kinasepro on July 1, 2007

WO/2007/072017 is from ICR and looks a little more polished then the earlier Chroma – quinoline series.

ClC1=C(N2CCN(CC(NC3=NC=CS3)=O)CC2)C4=C(NC(C5=CC=C(N6CCN(C)CC6)C=C5)=N4)N=C1

still no candidate though?

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