Kinase Chemistry – Just a year and a half behind the times.

Archive for July 31st, 2007

PDB Update

Posted by kinasepro on July 31, 2007

2pzy: MK2; BI; BMCL:

That p-loop interaction sure is interesting


and the s-o is 2.87Å.

2DWB: Aurora A; ANP; RSGI

Posted in PDB | 1 Comment »

S – – – – O

Posted by kinasepro on July 31, 2007

I thought this was pretty well known, but looking at some recent literature along with Ashutosh, I guess its worth highlighting. The short of it is that if you need it in plane maybe you aughta see what it looks like with a sulfur atom.

Dasatinib is one such example where the carbonyl is in plane with a heteroaromatic Sulfur atom, but there are plenty of more where that came from…

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Posted in General Interest | 8 Comments »