KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for July 31st, 2007

PDB Update

Posted by kinasepro on July 31, 2007

2pzy: MK2; BI; BMCL:

That p-loop interaction sure is interesting

O=C(C1=CC(C2=C(C(NC[C@@H]2C)=O)N3)=C3C=C1)NC4=NC(C(NCCN(C)C)=O)=CS4

and the s-o is 2.87Å.

2DWB: Aurora A; ANP; RSGI

Advertisements

Posted in PDB | 1 Comment »

S – – – – O

Posted by kinasepro on July 31, 2007

I thought this was pretty well known, but looking at some recent literature along with Ashutosh, I guess its worth highlighting. The short of it is that if you need it in plane maybe you aughta see what it looks like with a sulfur atom.

Dasatinib is one such example where the carbonyl is in plane with a heteroaromatic Sulfur atom, but there are plenty of more where that came from…

Read the rest of this entry »

Posted in General Interest | 8 Comments »