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Archive for July 24th, 2007

PDB Update

Posted by kinasepro on July 24, 2007

2PZI: AX-20017 in PknG, Biozentrum (University of Basel) & PSI; PNAS

O=C(C1=C(NC(C2CC2)=O)SC3=C1CCCC3)N

IC50 of ~0,5μM

AX-20017 was a hit, and optimized in: WO/2005/023818 by Axxima now owned by GPC. Some off-target activity on Aurora is described in the series, and here’s some related Flt3 inhibitors: BMCL

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