Kinase Chemistry – Just a year and a half behind the times.

Archive for July 22nd, 2007

Oximes from J&J

Posted by kinasepro on July 22, 2007

So J&J has a BMCL describing the amino-pyrimidine-oxime moiety as quinazoline isostere, and a there’s a handful of other applications describing the motif.   Here’s a Lapatinib-esque example where they describe the EGF activity: WO/2007/081630


< 2g/d plz

Posted in EGF, J&J | 6 Comments »