Kinase Chemistry – Just a year and a half behind the times.

TargaGen closes…

Posted by kinasepro on July 13, 2007

Closes a 40M series D that is. Kudos Pros. Some of the more recent thiazole apps like US20070161645 appear to my eye to be the Src/Abl backup brigade.


wt Abl 1.5 nM
T315I 18 nM

So you like pictures?


2 Responses to “TargaGen closes…”

  1. Are you sure those Ariad phosphonate esters aren’t actually dimethylphosphine oxides? [ArP(=O)(CH3)2]? I could be wrong, but Ariad always seemed to be into these kind of unusual functional groups, and I can’t quite remember….

  2. kinasepro said

    They describe both in Chem Biol Drug Des 2006, 46. But now that you mention it, the 2D image above is an ester, while the 3D image is the phosphine-oxide.

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