KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for July 7th, 2007

WO/2007/075567

Posted by kinasepro on July 7, 2007

A reader comment got me to take a closer look at the titled JnJ application.¬† I don’t see it making their blog, but given its similarity to a recent a Vertex application of course it’s going to make this one.

FC(C1=CC(C=CC=N2)=C2C=C1)(F)C3=NN=C4N3N=C(C5=CN(C)N=C5)C=C4

1 nM autophos

 regression @ 25 mg / kg ?  Them some lucky mice.

clogp= 1.28 MW=377

Yah, I’d say your compounds are getting jealous right about now.

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Posted in c-Met, J&J, Janssen | 16 Comments »