Kinase Chemistry – Just a year and a half behind the times.

PDB Update

Posted by kinasepro on June 5, 2007

Some kind of coincidence that this week’s update are all indazoles? Hmm…

2UZT Abbott; AKT;
2UZU A-443654

The real action with these is what’s going on with the indole though.

2UZU is A-443654 bound to PKA whilst Astex opened up a can of worms on the pka/pkb situation with a J. Molec. Biol. earlier this year (2JDR).


So just what is going on with that indole anyhow?


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