KinasePro

Kinase Chemistry – Just a year and a half behind the times.

PDB Update

Posted by kinasepro on June 5, 2007

Some kind of coincidence that this week’s update are all indazoles? Hmm…

2UZT Abbott; AKT;
2UZU A-443654
2UZV
2UZW

The real action with these is what’s going on with the indole though.

2UZU is A-443654 bound to PKA whilst Astex opened up a can of worms on the pka/pkb situation with a J. Molec. Biol. earlier this year (2JDR).

NC(COC1=CC(C2=CC3=C(NN=C3C)C=C2)=CN=C1)CC4=CNC5=C4C=CC=C5

So just what is going on with that indole anyhow?

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

 
%d bloggers like this: