KinasePro

Kinase Chemistry – Just a year and a half behind the times.

E7080

Posted by kinasepro on May 29, 2007

O=C(C1=CC2=C(OC3=CC=C(NC(NC4CC4)=O)C(Cl)=C3)C=CN=C2C=C1OC)N

US20070117842 is a polymorph application, and there’s been a fair amount of IP activity around the compound. Indications are its E7080: an oral PhI Vegf, FGF, Pdgf, C-Kit, etc compound which first touched down in WO/2004/080462.

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2 Responses to “E7080”

  1. polymorph application…you mean they are patenting a polymorph of an already patented compound? didn’t know about this.

  2. kinasepro said

    Ayyep, It has become a common practice of process groups. Different crystal forms can have different dissolution properties, and thus different pk. It might have something to do with extending the patent life, but I think its more to do with preventing others from attempting to claim they’ve found a better version of your drug.

    For KP its pretty good evidence that if a group went to all the trouble to find the best crystal form of a specific compound – its probably the one in the clinic.

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