KinasePro

Kinase Chemistry – Just a year and a half behind the times.

PDB Update

Posted by kinasepro on May 1, 2007

2GU8, AKT, Chiron, BMCL, 06, 4163

O=C(C1=CC=C(C2=NC(NC)=NC=C2)S1)N[C@@H](CC3=CC=C(Cl)C=C3Cl)CN

2OJ9, IGF-1R, BMS, BMCL, 07, 2317

O=C1C(C2=NC3=CC(N4C=CN=C4)=CC(C)=C3N2)=C(NCC5=NC=CC=C5)C=CN1

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One Response to “PDB Update”

  1. From the BMCL link it seems those AKT (ahem!) ligands could also be described as PKA selective inhibitors. From what they write, I am surprised they didn’t make any pyrimidin-6-ones, which should have targeted the serine in the active site (not present in PKA). Or maybe they did and it isn’t in the paper.

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