KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Iressa ®

Posted by kinasepro on April 8, 2007

Iressa ®, gefitinib, ZD-1839

COC1=CC2=NC=NC(NC3=CC=C(F)C(Cl)=C3)=C2C=C1OCCCN4CCOCC4

Discovery: Zeneca (UK) WO/1996/016960
US approval: May 2003
Label change: June 2005

FDA has approved new labeling for Iressa that states the medicine should be used only in cancer patients who have already taken the medicine and whose doctor believes it is helping them. New patients should not be given Iressa because in a large study Iressa did not make people live longer. There are other medicines for non-small cell lung cancer (NSCLC) that have shown an ability to make people live longer.

wiki; PDB: EGFR – 2ITY; Mutant EGFR: 2ITZ, 2ITO

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