KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Gleevec ®

Posted by kinasepro on April 8, 2007

Novartis mispells it ‘Glivec’ outside the US, but you can call it imatinib mesylate, STI-571, or even CGP-57148 if you like.

O=C(NC1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1)C4=CC=C(CN5CCN(C)CC5)C=C4

Discovery: 1992, CIBA-Geigy, Crystallography played no role in the discovery.
US Approval: May 2001

wiki; FDA; PDB: Abl 1IEP; Abl 1OPJ; cKit 1T46; Syk 1XBB; Abl 2HYY; Src 2OIQ

Also inhibits: c-Kit, Pdgfr-a,  LCK

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