Good call – as usual KP is little behind the curve. The authors on this application indeed appear to be from Chiron. Has Chir-265 beed described? They’ve been stumping for CHIR-258 for a while, but mum on the RAF series, far as I know.
Yup. They disclosed it last year’s AACR. Sorafenib rip off basically – urea isostere for the DFG-out and amide isostere off the pyridine. Except that it actually has P-Mek and P-Erk inhibition in cells at nM potencies. P-Kdr too. But of course.