KinasePro

Kinase Chemistry – Just a year and a half behind the times.

AP24534 In here?

Posted by kinasepro on February 25, 2007

Everyone looking at Abl these days is trying to wiggle their way around T315 and Ariad’s latest go is described in the app: WO/2007/021937 with a series of styrene-purines. They look to be a follow-on series to the earlier purine stuff described elsewhere.

CC1=CC=C(C(NC2=C(F)C=CC(C(F)(F)F)=C2)=O)C=C1/C=C/N3C=NC4=C3N=CN=C4NC5CC5

Structures for their two previous SRC/ABL leads: AP23464 and AP23451 were disclosed but afaik AP24534 has not.

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