KinasePro

Kinase Chemistry – Just a year and a half behind the times.

US20070032478

Posted by kinasepro on February 11, 2007

Allergan has a series of indolinones in US20070032478.  They don’t list the target, though, I speculated a couple weeks ago it  may be Vegf – perhaps purchasing selectivity with the tail piece – for AMD.

O=C(C1=CC(C)=NN1C)NC2=CC=CC(C(C3=CC(NC/4=O)=C(C=C3)C4=C\NC5=CC=C(N6CCN(C)CC6)C=C5)=O)=C2

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