Posted by kinasepro on January 28, 2007
Mitsubishi has an app covering the intermediates for their GSK3 Sanofi-Aventis stuff. I still think the spiro compounds are sexier, but the morpholines are further explored so here we have a pretty solid looking asymmetric method to make 2-aryl morpholines via CBS reduction:
Route starts on page 79 example 1, 2 & 5 shown here.
Array might have something to say with how novel the approach is, y’know given how they sell the (rac) stuff?