KinasePro

Kinase Chemistry – Just a year and a half behind the times.

WO2007006926

Posted by kinasepro on January 25, 2007

Just another pyrimidine series? Maybe, but Sanofi-Aventis has a bunch of these sulfonamides in WO/2007/006926. They’ve got an IKK collaboration Millenium with “MLN0415 a phase one inhaled IKK-beta inhibitor taking the lead, but this aint that.

O=S(C1=CC=C(NC2=NC=CC(NC3=CC=C(F)C=C3)=N2)C=C1)(N(C4CCN(CCP(OCC)(OCC)=O)CC4)C[C@H]5CCCN5)=O

They’re not all phosphonates, but this subseries has me crooking an eyebrow. Perhaps this is the AVE8680 Sanofi series, but I’d expect this app to have Sxx# given that its a French application… eh… Beats me.

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