KinasePro

Kinase Chemistry – Just a year and a half behind the times.

US20070015207

Posted by kinasepro on January 22, 2007

The triazolopyrimidine series hit the street with WO2005012304 where the chemistry was from Belgium, and Jannsen was calling them GSK3 inhibitors. Ahh, ’twas a simpler time… Then in WO/2006076442 they started claiming similar compounds: ‘produce a Fak/Cak enzyme inhibitory effect.’ So a) The series aint none too selective, b) there’s some subtle change that I’m not seeing where they can turn the activity around, c) GSK3 inhibitors ‘produce a fak/cak enzyme inhibitory effect,’ or of course d) I’m way over-thinking this. (yah, there is an indan in the earlier stuff too.)

O=C(NCCN(CC)CC)C1=CC=C(NC2=NC=C(N=NN3C4=CC5=C(CCC5)C=C4)C3=N2)C=C1 N#CCC1=CC(N2N=NC3=CN=C(NC4=CC=C(CN5CCN(C)CC5)C=C4)N=C32)=CC=C1

ClickClick – Beats me…

… but Kemia’s got some (gsk3 inhibitors with the core) in WO2006091737

ClC1=NC2=C(N=NN2C3=CC(CCC4)=C4C=C3)C=N162%

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