KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for January 14th, 2007

Got Spiro?

Posted by kinasepro on January 14, 2007

US20070010539 is a GSK3-beta application. This series goes back to ’01, and the pictured spiro compound hit the streets in ’05. Publications on these? Other then an expert opinion (which my library doesn’t carry) and them naming SAR502250 a preclinical development candidate (also in ‘05), I haven’t seen anything. While I don’t relish posting old news, the novel spiro architecture was enough to make KP lift an eyebrow.

O=C1C=C(C2=CC=NC=C2)N=C3N(C[C@H](O)C4=CC=CC=C4)C5(CCN(C)CC5)CCN31

Only they know if these spiro compounds are the lead structures, but it looks like a well developed chemical series with an interesting story to be told, and since they’re not talking… I will.

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