KinasePro

Kinase Chemistry – Just a year and a half behind the times.

US20070004762

Posted by kinasepro on January 10, 2007

Vertex has a series of Jak / Rock inhibitors… Of the 31 examples, this one looks somewhat selective for Jak3

C12=NC=NC(C3C4CCC(C4)C3)=C1C=CN2

fw 213.8 Ki < 500 nM

Thats ridiculous – I love it

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One Response to “US20070004762”

  1. milkshake said

    Maybe one could replace that bridge methylene in norbornene with NH bridge, and then smoke it…

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