KinasePro

Kinase Chemistry – Just a year and a half behind the times.

WO2006135796

Posted by kinasepro on December 21, 2006

‘Crystaline Forms’ of these HER1, 2, & 4 inhibitors. Interesting compounds. There’s already a BMCL on the series, and a Can J Chem on the route,

CC(C(NC(OC[C@@H]1COCCN1)=O)=C2)=C3N2N=CN=C3NC4=CC(C=NN5CC6=CC(F)=CC=C6)=C5C=C4

but this is the first I’ve heard of the morpholine.

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2 Responses to “WO2006135796”

  1. ebola1 said

    Nice core — should test this in more kinases — too late

  2. kinasepro said

    Heh, your likely referring to the fact that BMS has used this ‘6-5 heterocycle as a quinazoline isostere‘ motif to great effect, taking from it clinical candidates for Vegf/FGF (BMS-540215), preclinical candidates for p38, MEK inhibitors, C-Met inhibitors, and so on… Strangely few others seem willing to go near them – or maybe thats the idea.

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