KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for December 21st, 2006

WO2006134382

Posted by kinasepro on December 21, 2006

This is a process application via GSK for a P38 inhibitor. There’s a number of applications in this series since ’03. but to the best of my knowledge no publications.

CC(C(F)=CC(C(NC1=NOC=C1)=O)=C2)=C2C3=CC=C(C(NCC(C)(C)C)=O)C=N3

That’s usually a sign.

Posted in GSK, p38 | 2 Comments »

WO2006135796

Posted by kinasepro on December 21, 2006

‘Crystaline Forms’ of these HER1, 2, & 4 inhibitors. Interesting compounds. There’s already a BMCL on the series, and a Can J Chem on the route,

CC(C(NC(OC[C@@H]1COCCN1)=O)=C2)=C3N2N=CN=C3NC4=CC(C=NN5CC6=CC(F)=CC=C6)=C5C=C4

but this is the first I’ve heard of the morpholine.

Posted in BMS, EGF | 2 Comments »

The Thursday List

Posted by kinasepro on December 21, 2006

WO/2006/135796
WO/2006/135721
WO/2006/135719
WO/2006/135713
WO/2006/135649
WO/2006/135646
WO/2006/135644
WO/2006/135627
WO/2006/135604
WO/2006/134382
WO/2006/133885
WO/2006/135629
WO/2006/134469
US20060287381
US20060287370
US20060287355
US20060287354
US20060287343
US20060287339
US20060287295

Posted in Application List | Leave a Comment »