KinasePro

Kinase Chemistry – Just a year and a half behind the times.

KC706

Posted by kinasepro on December 13, 2006

Hi Kemia, I’m going to have to do a little digging to get to the bottom of this KC706 compound that I’m not familar with… but that will have to wait for another day. Cute attempt with the allosteric p38 video anyhow.

>> update >> I don’t have the structure of KC706, but its likely from their series of ‘cytokine inhibitor‘ patent apps which are BIRB796 rips.

burn

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4 Responses to “KC706”

  1. weirdo said

    Kemia? Kemia? You blogged a Kemia report?

    Yikes! Standards, boy, standards!

  2. kinasepro said

    heh, Well Kemia just finished a series C for 30 million. That makes them a 60 something million dollar company with a Ph ii compound… That aint too bad.

    Hoping they don’t burn it all on this p38 compound they will have some left to spend getting the GSK3 program ready for primetime. I don’t know anything about the GPCR stuff, but I was a little dissapointed to see all this hoop-la for this ‘allosteric inihitor technology’ when we’re clearly just talking about a DFG-out birb analog. 😦

    eh?

  3. just hangin said

    If it is truely a BIRB ripoff, then there is no chance of success — just a soluble urea toxic beast that when dosed high enough is a major problem.

  4. weirdo said

    Yeah, but a Kemia Ph 2 molecule doesn’t equal a Big Pharma Ph 2 molecule. Maybe they’ll get lucky, but how hard was it to find a really potent p38 inhibitor that “kind of” looks good enough to try out in the clinic?

    A biotech working on p38 is a biotech that is desparate.

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