Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on December 10, 2006

Ok Merck, so what’s with the aldehyde? Ahhah, I see you already dropped the dime in Biochemistry back in ’05. ‘Reductive amination’ with no reducing agent. Somebody needs to break these kinds of things down for me, since I still don’t get it.


Earlier applications in the series: WO200500937, WO2005009957

2 Responses to “US20060276514”

  1. milkshake said

    Looks more like reversible covalent adducts (lysine-side-chain adduct in active site). They determined the location by stabilizing the adduct by addition of borohydride and digesting the protein

  2. kinasepro said

    Ahh I get it, it sounded to me on first read that they were saying it the inhibitor bound via reductive amination.

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