Kinase Chemistry – Just a year and a half behind the times.

Archive for December 10th, 2006


Posted by kinasepro on December 10, 2006

G’day Kinacia (formerly Thrombogenix) I see you guys made a splash with TGX-221, a selective Pi3K-b inhibitor. And now it looks like you’ve been fine tuneing. I’m thinking the Bioorg Med Chem Lett will look something like:

LY294002 is: 1E7V

221: WO/2001053266

Posted in biotech, pi3k | 6 Comments »


Posted by kinasepro on December 10, 2006

Ok Merck, so what’s with the aldehyde? Ahhah, I see you already dropped the dime in Biochemistry back in ’05. ‘Reductive amination’ with no reducing agent. Somebody needs to break these kinds of things down for me, since I still don’t get it.

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Posted in IGF, Merck & Co. | 2 Comments »