Kinase Chemistry – Just a year and a half behind the times.

Swing Rho,

Posted by kinasepro on December 5, 2006

Sweet Chariot… Ehhem, umm, uhh, pardon me, pardon me, though its not unlike Kinasepro to break into song in the presence of greatness, so perhaps you’ll grant me this.

The PDB has been hot lately, this week its Part two in a Rho series with Y27632 (a ROCK inhibitor) bound to Rho: 2H9V.

 2FSU was the first Rho xray published via the same group earlier this year. Also of note, 2GNJ tried to model Rho with a 5-fold mutant of PKA bound to this same inhibitor. By the looks of this one, they got it pretty close.

There’s also a string of p38 mutants: 2FSL, 2FSM, 2FSO, 2FST,


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