Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on November 20, 2006

Hey Vertex, Interesting Aurora 2,3 inhibitors. I see these come from a series you’ve been on for a while (WO2006058074, WO2005095400). VX680 backups? Hard to tell with how many apps you guys publish. Interesting compounds anyhow.

App includes the pyrazolopyrazines, a core which Roche used first for p38 inhibitors a while back (US2005197340). 1UNG may give a clue to how these are binding.


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