KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for November 16th, 2006

Tykerb

Posted by kinasepro on November 16, 2006

>>update>> 03/14/07: TykerB FDA Approved

Tykerb / GW2016 / lapatinib / is a step closer to market and Xcovery is on it.

They had a C&EN cover back in August, and you can check out the ’06 ASCO report from their renal cell carcinoma Ph iii. (scroll a bit for slides and even a video.) But the highlight from that trial was: 1.25g / day and it didn’t work 😦

ClC1=CC(NC2=NC=NC3=CC=C(C4=CC=C(CNCCS(=O)(C)=O)O4)C=C32)=CC=C1OCC5=CC(F)=CC=C5

PDB: 1XKK

Posted in clinical, EGF, GSK | 4 Comments »