KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Plethora ‘o’ PDB’s

Posted by kinasepro on November 15, 2006

6 good one’s released today:

2J50 PHA-739358 bound to Aurora-2 (Nerviano’s phase 1 compound)

O=C(NC1=C2C(CN(C([C@H](OC)C3=CC=CC=C3)=O)C2)=NN1)C4=CC=C(N5CCN(C)CC5)C=C4

2EXC a JNK3 xray

2I0E A staurosporine analog with non-staurosporine like binding in PKC-b. Not the first of its kind but nonetheless interesting, particularly given that Cephalon is in the clinic with one of these.

2J4Z PHA-680626 bound to Aurora-2

2J7T SU11274 (Met inhibitor) bound to STK-10

2J90 A tetracyclic inhibitor bound to Zip kinase. Interesting magnesium atom between the imidazole and a lysine residue.

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