Plethora ‘o’ PDB’s
Posted by kinasepro on November 15, 2006
6 good one’s released today:
2J50 PHA-739358 bound to Aurora-2 (Nerviano’s phase 1 compound)
2EXC a JNK3 xray
2I0E A staurosporine analog with non-staurosporine like binding in PKC-b. Not the first of its kind but nonetheless interesting, particularly given that Cephalon is in the clinic with one of these.
2J4Z PHA-680626 bound to Aurora-2
2J90 A tetracyclic inhibitor bound to Zip kinase. Interesting magnesium atom between the imidazole and a lysine residue.