KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Archive for November 15th, 2006

US20060252782

Posted by kinasepro on November 15, 2006

Hi Schering AG, err Bayer, err, whoever you are these days, TIE2 / VEGF Sulfoximine macrocycles I see. Those 5% cyclizations are going to need a little work… But what I really want to see is you guys resolve the enantiomers!

O=S(C1=CC=CC(NC2=NC3=C(C4=CC=C(NC(NC5=CC(C(F)(F)F)=CC=C5F)=O)C=C4)C=N2)=C1)(CCCCN3)=N

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Posted in Schering AG, TIE2, VEGF | 3 Comments »

Plethora ‘o’ PDB’s

Posted by kinasepro on November 15, 2006

6 good one’s released today:

2J50 PHA-739358 bound to Aurora-2 (Nerviano’s phase 1 compound)

O=C(NC1=C2C(CN(C([C@H](OC)C3=CC=CC=C3)=O)C2)=NN1)C4=CC=C(N5CCN(C)CC5)C=C4

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Posted in Nerviano, PDB | Leave a Comment »