KinasePro

Kinase Chemistry – Just a year and a half behind the times.

AMG706

Posted by kinasepro on November 6, 2006

Update>> They named it: Motesanib diphosphate

Xcovery has the roundup on AMG706. I tend to think it’s a little apples and oranges to try and line it up against Sutent at this point. Heck it’s been nearly a year since release and noones come out and said Sutent is really any better then Nexavar.

The compound is second generation to ptk787; a VEGF inhibitor which failed to meet a Phase III endpoint.

There’s an article on the preclinical stuff: Cancer Research (2006), 66(17), 8715

Frankly KP is shocked that noone has yet published an application claiming the Bayer modification, woops scratch that, looks like Bayer has an application floating around: WO2006002383, but they don’t have the magic indoline.

ClC(C=C1)=CC=C1NC2=NN=C(C3=C2C=CC=C3)CC4=C=NC=C4 O=C(NC1=CC(NCC2(C)C)=C2C=C1)C(C=CC=N3)=C3NCC4=CC=NC=C4 O=C(C1=NC=CC(CNC2=CC=CC=C2C(NC3=CC=C(OC(F)(F)O4)C4=C3)=O)=C1)NC5CC5

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One Response to “AMG706”

  1. milkshake said

    Indolinone is like a mother in law – it can be helpful but your life is easier if there is none.

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