Posted by kinasepro on November 6, 2006
Update>> They named it: Motesanib diphosphate
Xcovery has the roundup on AMG706. I tend to think it’s a little apples and oranges to try and line it up against Sutent at this point. Heck it’s been nearly a year since release and noones come out and said Sutent is really any better then Nexavar.
The compound is second generation to ptk787; a VEGF inhibitor which failed to meet a Phase III endpoint.
There’s an article on the preclinical stuff: Cancer Research (2006), 66(17), 8715
Frankly KP is shocked that noone has yet published an application claiming the Bayer modification, woops scratch that, looks like Bayer has an application floating around: WO2006002383, but they don’t have the magic indoline.
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