KinasePro

Kinase Chemistry – Just a year and a half behind the times.

US20060247250

Posted by kinasepro on November 4, 2006

Hi TargeGen, I see you’ve got another handful of compounds in another SRC inhibitor application. I guess selectivity has never been a real big thing down there in San Diego. These look suspiciously like dasatinib and are just the ‘reverse-amides’ from an earlier TG series (WO2006101977). I wonder what the ABL inhibition looks like for these…

Nice work finding a niche that doesn’t seem to have been covered anyhow.

O=C(NC1=C(C=CC=C1Cl)Cl)C(C=N2)=CN=C2NC3=CC=C(S(=O)(NCCN4CCCC4)=O)C=C3

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