Posted by kinasepro on November 3, 2006
Hey Exelixis, sorry to hear about your Phase II VEGF / PDGF / FGF suspension. ‘cardiovascular events’ = HERG? Nah, Probably some of that vegf mediated hypertension. Looks like we’ll here more on the 9th.
XL999 is a second generation Sutent-like molecule that brings in greater potency and adds some oncogenic kinases to its target profile at the expense of being an IV drug. There’s a lot of people who will be keeping a close eye on what happens here, since this compound is not the only second generation VEGF / etc. cancer therapy in development. From phase 1: