KinasePro

Kinase Chemistry – Just a year and a half behind the times.

XL999

Posted by kinasepro on November 3, 2006

Hey Exelixis, sorry to hear about your Phase II VEGF / PDGF / FGF suspension. ‘cardiovascular events’ = HERG? Nah, Probably some of that vegf mediated hypertension. Looks like we’ll here more on the 9th.

XL999 is a second generation Sutent-like molecule that brings in greater potency and adds some oncogenic kinases to its target profile at the expense of being an IV drug. There’s a lot of people who will be keeping a close eye on what happens here, since this compound is not the only second generation VEGF / etc. cancer therapy in development. From phase 1:


O=C1NC2=CC=C(NC3CCN(CC)CC3)C=C2/C1=C(C4=NC(C)=CN4)\C5=CC(F)=CC=C5

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

 
%d bloggers like this: