Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on November 2, 2006

Hi AstraZeneca, Nice IGFR inhibitors. They could be 20 uM for all I know, but they’ve got it all. Pyrimidine, pyrazine, and pyridines, pyrrolidine, isoxazole, and even a chiral center all on a sub-500 MW molecule! Hot Damn, strap on a morpholine and I’ll have died and gone to heaven. WO2006109026, WO2006106307, WO2006100461, WO2005040159.

Some of the points of diversity are highlighted, not entirely sure whats going on with these. Pretty cool though. The ’05 application references Vertex: WO2002022601

One Response to “WO2006109026”

  1. Ashutosh said

    I wonder what the solvation energies of those babies are. With all those heteros, I wouldn’t be surprised if they refuse to part away from water into the active site of the protein.

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