KinasePro

Kinase Chemistry – Just a year and a half behind the times.

Couple-a-new-PDB’s

Posted by kinasepro on October 24, 2006

2BDF, and 2BDJ

These are the SRC / Abl phosphine oxide bearing purines from Ariad. Good stuff with a free bonus link to the published discussion: Chem Biol Drug Des 2006, 46.

OC1=CC=CC(CCN2C=NC3=C2N=C(C4CCCC4)N=C3NC5=CC=C(P(OC)(OC)=O)C=C5)=C1x-ray crystallography, SRC/ABL AP23464 AP23451 CCN2C=NC1=C(NC3=CC=C(P(O)(CP(O)(O)=O)=O)C=C3)N=C(C4CCC(N)CC4)N=C12 CP(C(C=C5)=CC=C5NC1=C(N=CN2CCC3=CC(O)=CC=C3)C2=NC(C4CCCC4)=N1)(C)=O

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