Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on October 14, 2006

Hello there Amgen,

Welcome to Kinasepro, and thanks for playing the ‘hide the structure’ game.  (names only no structures given)  You’re  Markush makes it look like a Cyclacel rip, and KP wouldn’t be at all surprised if you started looking around near there, but I like how you’ve taken it a good bit further.  The region that I would consider ‘solvent exposed’ isn’t the typical yada-yada, but there are a few polar residues out there which it seems you’re likely picking up with those imidazolones.  The benzothiazole is a nice touch, and I’m also glad you were able to fit first and second generation compounds into the same application, less money to the layers is always good eh?

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