Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on October 14, 2006

So Kinasepro’s homework for the evening was to catch up on some of the PLK1 application literature just to see what’s out there. Expecting to see some Schering rip-offs, I was surprised to find a robust cast of characters playing there parts on the Polo-like stage.

Structurally it appears that there’s a cystein residue on the inside of the p-loop which most of these applications appear to attempt to exploit in one fasion or another.

Don’t care about PLK1? Then you may want to check back in a bit…

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