Kinase Chemistry – Just a year and a half behind the times.


Posted by kinasepro on October 4, 2006

Hi BMS, Yet another EGF inhibiting Quinazoline series, I see?

I had the good fortune to work with Ping Chen a few thousand years ago, in a galaxy far far away. Ping (a coinventor on this patent) is one of those brilliant BMS ‘Schlessinger Guys’ with a work ethic of a pack mule. I mean, how many industry guys do you know that are taking NMR’s at 8 O’clock every night?

Looks as though they’re sticking a piperidine in the ribose pocket.

I like it, but I’m surprised that I don’t recall seeing someone pull this off before.


Overlays nicely in Pymol to 2GS7 using 1XKK for the alignment.

example overlay


2 Responses to “US20060217369”

  1. milkshake said

    Hi Kinasepro,

    looks like we are in the same field.

    Please keep going at it, this site is potentially going to be very useful (and it is aestheticaly pleasing already). Three cheers to you, man.

  2. kinasepro said

    Hi Milks, I’ve been meaning to get this going for a while. Thanks for your blog as well!

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